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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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World-2DPAGE Portal
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Searching in 'USC-OGP 2-DE database' for entry
matching:
HPRT_HUMAN
USC-OGP 2-DE database
:
HPRT_HUMAN
HPRT_HUMAN
General information about the entry
View entry in simple text format
Entry name
HPRT_HUMAN
Primary accession number
P00492
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Hypoxanthine-guanine phosphoribosyltransferase; Short=HGPRT; Short=HGPRTase; EC=2.4.2.8;.
Gene name
Name=HPRT1
Synonyms=HPRT
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_6-11
{PLATELET 6-11}
Homo sapiens (Human)
map experimental info
PLATELET_6-11
MAP LOCATIONS:
SPOT OGP-1015
:
pI=6.08; Mw=25397
Cross-references
UniProtKB/Swiss-Prot
P00492; HPRT_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
HPRT_HUMAN
Primary accession number
P00492
Secondary accession number(s)
A6NHF0 B2R8M9
Sequence was last modified on
January 23, 2007 (version 2)
Annotations were last modified on
March 15, 2017 (version 196)
Name and origin of the protein
Description
RecName: Full=Hypoxanthine-guanine phosphoribosyltransferase; Short=HGPRT; Short=HGPRTase; EC=2.4.2.8;
Gene name
Name=HPRT1
Synonyms=HPRT
Encoded on
Name=HPRT1; Synonyms=HPRT
Keywords
3D-structure
;
Acetylation
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Disease mutation
;
Glycosyltransferase
;
Gout
;
Isopeptide bond
;
Magnesium
;
Metal-binding
;
Nucleotide-binding
;
Phosphoprotein
;
Purine salvage
;
Reference proteome
;
Transferase
;
Ubl conjugation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M31642; AAA52690.1
; -; mRNA
EMBL
M26434; AAA36012.1
; -; Genomic_DNA
EMBL
AK313435; BAG36226.1
; -; mRNA
EMBL
BT019350; AAV38157.1
; -; mRNA
EMBL
AY780550; AAV31777.1
; -; Genomic_DNA
EMBL
AC004383; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
CH471107; EAX11761.1
; -; Genomic_DNA
EMBL
BC000578; AAH00578.1
; -; mRNA
EMBL
M12452; AAA52691.1
; -; Genomic_DNA
EMBL
S79313; AAB21289.1
; -; Genomic_DNA
EMBL
L29383; AAB59391.1
; -; mRNA
EMBL
L29382; AAB59392.1
; -; mRNA
EMBL
S60300; AAC60591.2
; -; mRNA
CCDS
CCDS14641.1; -
; .
PIR
A32728; RTHUG
; .
RefSeq
NP_000185.1; NM_000194.2
; .
UniGene
Hs.412707; -
; .
PDB
1BZY; X-ray
; 2.00 A; A/B/C/D=2-218
PDB
1D6N; X-ray
; 2.70 A; A/B=5-218
PDB
1HMP; X-ray
; 2.50 A; A/B=2-218
PDB
1Z7G; X-ray
; 1.90 A; A/B/C/D=2-218
PDB
2VFA; X-ray
; 2.80 A; A/B=49-160
PDB
3GEP; X-ray
; 2.60 A; A/B=2-218
PDB
3GGC; X-ray
; 2.78 A; A/B=2-218
PDB
3GGJ; X-ray
; 2.60 A; A/B=2-218
PDB
4IJQ; X-ray
; 2.00 A; A/B/C/D=2-218
PDB
4KN6; X-ray
; 2.73 A; A=3-218
PDB
4RAB; X-ray
; 2.26 A; A/B/C/D=2-218
PDB
4RAC; X-ray
; 2.05 A; A/B/C/D=2-218
PDB
4RAD; X-ray
; 2.00 A; A/B/C/D/E/F/G/H=2-218
PDB
4RAN; X-ray
; 2.55 A; A/B/C/D=2-218
PDB
4RAO; X-ray
; 1.87 A; A/B/C/D=2-218
PDB
4RAQ; X-ray
; 2.53 A; A/B/C/D=2-218
PDB
5BRN; X-ray
; 2.30 A; A/B/C/D=1-218
PDB
5BSK; X-ray
; 2.61 A; A/B/C/D=1-218
PDB
5HIA; X-ray
; 1.77 A; A/B/C/D=1-218
PDBsum
1BZY; -
; .
PDBsum
1D6N; -
; .
PDBsum
1HMP; -
; .
PDBsum
1Z7G; -
; .
PDBsum
2VFA; -
; .
PDBsum
3GEP; -
; .
PDBsum
3GGC; -
; .
PDBsum
3GGJ; -
; .
PDBsum
4IJQ; -
; .
PDBsum
4KN6; -
; .
PDBsum
4RAB; -
; .
PDBsum
4RAC; -
; .
PDBsum
4RAD; -
; .
PDBsum
4RAN; -
; .
PDBsum
4RAO; -
; .
PDBsum
4RAQ; -
; .
PDBsum
5BRN; -
; .
PDBsum
5BSK; -
; .
PDBsum
5HIA; -
; .
ProteinModelPortal
P00492; -
; .
SMR
P00492; -
; .
BioGrid
109488; 27
; .
IntAct
P00492; 15
; .
MINT
MINT-1443310; -
; .
STRING
9606.ENSP00000298556; -
; .
BindingDB
P00492; -
; .
ChEMBL
CHEMBL2360; -
; .
DrugBank
DB02309; 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine
; .
DrugBank
DB04356; 9-Deazaguanine
; .
DrugBank
DB01632; Alpha-Phosphoribosylpyrophosphoric Acid
; .
DrugBank
DB00993; Azathioprine
; .
DrugBank
DB01033; Mercaptopurine
; .
DrugBank
DB00352; Tioguanine
; .
iPTMnet
P00492; -
; .
PhosphoSitePlus
P00492; -
; .
SwissPalm
P00492; -
; .
BioMuta
HPRT1; -
; .
DMDM
123497; -
; .
OGP
P00492; -
; .
REPRODUCTION-2DPAGE
IPI00218493; -
; .
EPD
P00492; -
; .
MaxQB
P00492; -
; .
PaxDb
P00492; -
; .
PeptideAtlas
P00492; -
; .
PRIDE
P00492; -
; .
TopDownProteomics
P00492; -
; .
DNASU
3251; -
; .
Ensembl
ENST00000298556; ENSP00000298556
; ENSG00000165704; .
GeneID
3251; -
; .
KEGG
hsa:3251; -
; .
UCSC
uc004exl.5; human
; .
CTD
3251; -
; .
DisGeNET
3251; -
; .
GeneCards
HPRT1; -
; .
GeneReviews
HPRT1; -
; .
HGNC
HGNC:5157; HPRT1
; .
HPA
CAB012200; -
; .
HPA
HPA006360; -
; .
MalaCards
HPRT1; -
; .
MIM
300322; phenotype
; .
MIM
300323; phenotype
; .
MIM
308000; gene
; .
neXtProt
NX_P00492; -
; .
OpenTargets
ENSG00000165704; -
; .
Orphanet
79233; Hypoxanthine guanine phosphoribosyltransferase partial deficiency
; .
Orphanet
510; Lesch-Nyhan syndrome
; .
PharmGKB
PA29427; -
; .
eggNOG
KOG3367; Eukaryota
; .
eggNOG
COG0634; LUCA
; .
GeneTree
ENSGT00390000017323; -
; .
HOGENOM
HOG000236521; -
; .
HOVERGEN
HBG000242; -
; .
InParanoid
P00492; -
; .
KO
K00760; -
; .
OMA
DIAYVGF; -
; .
OrthoDB
EOG091G0K6K; -
; .
PhylomeDB
P00492; -
; .
TreeFam
TF313367; -
; .
BioCyc
MetaCyc:HS09275-MONOMER; -
; .
BRENDA
2.4.2.8; 2681
; .
Reactome
R-HSA-74217; Purine salvage
; .
SABIO-RK
P00492; -
; .
UniPathway
UPA00591; UER00648
; .
ChiTaRS
HPRT1; human
; .
EvolutionaryTrace
P00492; -
; .
GeneWiki
Hypoxanthine-guanine_phosphoribosyltransferase; -
; .
GenomeRNAi
3251; -
; .
PRO
PR:P00492; -
; .
Proteomes
UP000005640; Chromosome X
; .
Bgee
ENSG00000165704; -
; .
CleanEx
HS_HPRT1; -
; .
ExpressionAtlas
P00492; baseline and differential
; .
Genevisible
P00492; HS
; .
GO
GO:0005737; C:cytoplasm
; IDA:UniProtKB; .
GO
GO:0005829; C:cytosol
; IDA:HPA; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0052657; F:guanine phosphoribosyltransferase activity
; IDA:UniProtKB; .
GO
GO:0004422; F:hypoxanthine phosphoribosyltransferase activity
; IDA:UniProtKB; .
GO
GO:0042802; F:identical protein binding
; IPI:IntAct; .
GO
GO:0000287; F:magnesium ion binding
; IDA:UniProtKB; .
GO
GO:0000166; F:nucleotide binding
; IEA:UniProtKB-KW; .
GO
GO:0042803; F:protein homodimerization activity
; IPI:UniProtKB; .
GO
GO:0006168; P:adenine salvage
; IEA:Ensembl; .
GO
GO:0021954; P:central nervous system neuron development
; IEA:Ensembl; .
GO
GO:0021895; P:cerebral cortex neuron differentiation
; IEA:Ensembl; .
GO
GO:0019835; P:cytolysis
; IEA:Ensembl; .
GO
GO:0048813; P:dendrite morphogenesis
; IEA:Ensembl; .
GO
GO:0042417; P:dopamine metabolic process
; IEA:Ensembl; .
GO
GO:0046038; P:GMP catabolic process
; IDA:UniProtKB; .
GO
GO:0007625; P:grooming behavior
; IEA:Ensembl; .
GO
GO:0006178; P:guanine salvage
; IDA:UniProtKB; .
GO
GO:0046100; P:hypoxanthine metabolic process
; IMP:UniProtKB; .
GO
GO:0043103; P:hypoxanthine salvage
; IDA:UniProtKB; .
GO
GO:0046040; P:IMP metabolic process
; IDA:UniProtKB; .
GO
GO:0032264; P:IMP salvage
; IEA:UniProtKB-UniPathway; .
GO
GO:0007626; P:locomotory behavior
; IEA:Ensembl; .
GO
GO:0046651; P:lymphocyte proliferation
; IEA:Ensembl; .
GO
GO:0045964; P:positive regulation of dopamine metabolic process
; IMP:UniProtKB; .
GO
GO:0051289; P:protein homotetramerization
; IDA:UniProtKB; .
GO
GO:0006164; P:purine nucleotide biosynthetic process
; IMP:UniProtKB; .
GO
GO:0006166; P:purine ribonucleoside salvage
; IMP:UniProtKB; .
GO
GO:0043101; P:purine-containing compound salvage
; TAS:Reactome; .
GO
GO:0001975; P:response to amphetamine
; IEA:Ensembl; .
GO
GO:0021756; P:striatum development
; IEA:Ensembl; .
CDD
cd06223; PRTases_typeI
; 1; .
Gene3D
3.40.50.2020; -
; 1; .
InterPro
IPR005904; Hxn_phspho_trans
; .
InterPro
IPR000836; PRibTrfase_dom
; .
InterPro
IPR029057; PRTase-like
; .
Pfam
PF00156; Pribosyltran
; 1; .
SUPFAM
SSF53271; SSF53271
; 1; .
TIGRFAMs
TIGR01203; HGPRTase
; 1; .
PROSITE
PS00103; PUR_PYR_PR_TRANSFER
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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